Hepatoprotective Effect of Polyunsaturated Fatty Acids against Repeated Subacute Acetaminophen Dosing in Rats

Omega-3 polyunsaturated fatty acids are essential fatty acids offering multiple health benefits. They form an integral part of cell membrane and are indispensable for normal metabolism. Fish oil and flaxseed oil are among few dietary sources of these fatty acids. In present investigation, hepatoprotective potential of omega-3 fatty acids in the form of flaxseed oil and fish oil was assessed against repeated acetaminophen dosing in rats. Administration of flaxseed oil or fish oil prevented hepatic damage with marked improvement in hepatic function and normalization of lipid profiles in serum and liver. Administration of these oils normalized oxidative stress through improvements in levels of anti-oxidant enzymes and oxidative stress markers. Histological analysis showed absolutely normal hepatic architecture in flaxseed oil and fish oil treated animals and signify hepatoprotective effect of these supplements. This study is the first report of analysis of hepatoprotective potential of two different nutritional supplements of omega-